Phnom Nam Lyr Wildlife Sanctuary is a large protected area in Mondulkiri Province, Cambodia, established in 1993. It is close to Village I, Bou Sra Commune near the Pech Chreada District bordering Vietnam.

It covers an area of 509.57 km (196.75 sq mi) with elevations from 320 to 1,070 m (1,050 to 3,510 ft), and includes Phnom Nam Lyr within its borders. It is threatened by illegal logging.