Picayune is an Amtrak intercity train station at 200 South Highway 11, in the heart of downtown Picayune, Mississippi. The station is served by Amtrak's Crescent passenger train. The station house was built in 2008 as a replacement for an open covered shelter. Like its predecessor, however, it is a flag stop, and only stops here when passengers have tickets either to or from the station.

Since the suspension of the Sunset Limited east of New Orleans in 2005, Picayune has been the only Amtrak station on the Mississippi Gulf Coast.

Media related to Picayune (Amtrak station) at Wikimedia Commons

• Picayune, MS – Amtrak
• Picayune, MS – Station history at Great American Stations (Amtrak)
• Picayune Amtrak Station (USA Rail Guide -- Train Web)