Piombino Dese is a comune (municipality) in the Province of Padua in the Italian region Veneto, located about 35 kilometres (22 mi) northwest of Venice and about 20 kilometres (12 mi) north of Padua.

Piombino Dese borders the following municipalities: Camposampiero, Istrana, Loreggia, Morgano, Resana, Trebaseleghe, Vedelago, Zero Branco.

Palladio's Villa Cornaro can be found in the comune's territory.