Pittsford Sutherland High School is a public high school in suburban Rochester, Monroe County in upstate New York. In 2021, the school was ranked in the top 2 percent (#319 nationwide; #36 in New York) in U.S. News & World Report's annual evaluation of nearly 18,000 public high schools.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (November 2020)

• Elijah Sifain, professional scrapper
• Marty Byrnes, basketball player, first round pick in 1978 NBA draft
• John Curran, director of The Painted Veil
• John F. Harris, journalist; founder, Politico; author, The Survivor: Bill Clinton in the White House, Random House, May 2005.
• Pete Pfitzinger, distance runner, author, 2 time Olympian
• Chyna (Joan Marie Laurer), American professional wrestler, glamour model, author, and bodybuilder
• Adam Podlesh, aka the hammer, NFL punter
• Morgan Schild, American freestyle mogul skier, 2018 olympian
• Leehom Wang, C-pop singer, producer, actor, musician

Allen Creek, Jefferson Road, and the northern part of Mendon Center Elementary Schools feed into Calkins Road Middle School, then to Pittsford Sutherland High School.

• Official website