Plymouth Historic District is a national historic district located in Plymouth, Washington County, North Carolina. The district encompasses 258 contributing buildings, 5 contributing sites, and 1 contributing structure in the central business district and surrounding residential sections of Plymouth. It was largely developed between about 1880 and 1930 and includes notable examples of Colonial Revival, Bungalow / American Craftsman and Late Victorian style architecture. Located in the district are the separately listed Latham House, Perry-Spruill House, and Washington County Courthouse. Other notable buildings include the Hornthal-Owens Building (c. 1885), Blount Building (c. 1916), Atlantic Coast Line Railroad Station (1923), Davenport-Davis House (c. 1898), Robert Ward Johnston House (1924), Latham-Brinkley House (1883), Plymouth United Methodist Church and Cemetery (c. 1860s), Grace Episcopal Church and Cemetery (1860-1861, 1892-1893) designed by Richard Upjohn, New Chapel Baptist Church (1924), Agricultural Building (1936-1937) constructed through the Works Progress Administration, Plvmouth Railroad Station (1927), Brinkley Commercial Block (1926), and Clark-Chesson House (c. 1810).

It was listed on the National Register of Historic Places in 1991.