Ponca City High School is a public high school that serves approximately 1,500 students in grades 9–12, located in Ponca City, Oklahoma. The current main principal is Thad Dilbeck.

The school's boundary includes Ponca City and White Eagle.

The school operates on a semester schedule. Students attend six, 55-minute periods daily and also attend a 40-minute MUST (Mandatory Uninterrupted Study Time) period daily. A minimum of 46 credits is required for graduation. Ponca City High School students are called "Wildcats," a title that means hard work, perseverance, and extreme loyalty to the school, embodied by the school mascot "Willie" the Wildcat.

Notable alumni

• Hub Andrews, professional baseball player
• Douglas Blubaugh, Olympic Wrestling Gold Medal winner, 1960
• June Cobb, CIA informant
• Don Nickles, United States Senator from Oklahoma
• Jake McNiece, World War II paratrooper and leader of the Filthy Thirteen
• Mike Thompson, baseball player
• Lara Teeter, Tony Award nominee
• Anthony Taylor, Roman Catholic Bishop
• Shelby Wilson, Olympic Wrestling Gold Medal winner, 1960
• Richard E. Killblane, military historian and author
• Candy Loving, 25th Anniversary Playboy Playmate