The Pope Pius XII Catholic Center is a religious facility located along United Nations Avenue in Manila, Philippines. It was designed by José María Zaragoza (1912-1994), a noted architect and National Artist of the Philippines.

The facility was inaugurated on August 26, 1964. It has been used as a venue for plenary assemblies by Catholic bishops.

The National Museum of the Philippines formally declared the facility as an important cultural property in 2024.