Portalegre District (Portuguese: Distrito de Portalegre [puɾtɐˈlɛɣɾɨ] ) is located in the east of Portugal. The district capital is the city of Portalegre.

As of 2021, it is the least populous district of Portugal. It borders Spain.

The district is composed of 15 municipalities:

• Alter do Chão
• Arronches
• Avis
• Campo Maior
• Castelo de Vide
• Crato
• Elvas
• Fronteira
• Gavião
• Marvão
• Monforte
• Nisa
• Ponte de Sor
• Portalegre
• Sousel

Summary of election results from Portalegre district, 1976–2022

Parties	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S	%	S
	1976		1979		1980		1983		1985		1987		1991		1995		1999		2002		2005		2009		2011		2015		2019		2022
PS	41.9	3	29.8	1	32.4	1	38.5	2	23.7	1	25.1	1	33.5	1	50.5	2	51.2	2	45.3	2	54.9	2	38.3	1	32.4	1	42.4	1	44.7	2	47.2	2
PSD	10.1		In AD				19.1	1	20.9	1	37.4	1	38.9	2	23.4	1	22.5	1	30.6	1	20.2		23.8	1	32.5	1	In PàF		20.1		23.2
PCP/APU/CDU	22.0	1	29.4	1	26.1	1	28.7	1	25.2	1	20.9	1	15.2		14.0		15.0		12.4		12.1		12.9		12.8		12.2		8.1		7.6
AD			32.1	2	33.4	2
PàF																											27.6	1
Total seats	4								3												2
Source: Comissão Nacional de Eleições

39°17′28″N 7°25′55″W / 39.29111°N 7.43194°W / 39.29111; -7.43194