The Portuguesa River (Spanish: Río Portuguesa, also Río la Portuguesa, Río de la Portuguesa) is a river of Venezuela. It is part of the Orinoco River basin, and is a tributary of the Apure River (which is, in turn, a tributary of the Orinoco).

Legend has it that the river's name originated from a woman from Portugal who drowned in its waters. In turn, the river's name is the origin of the name of the Venezuelan state of Portuguesa.

• List of rivers of Venezuela

• Rand McNally, The New International Atlas, 1993.

7°56′17″N 67°32′20″W / 7.9381°N 67.5389°W / 7.9381; -67.5389