Prince Charles Strait is a strait 9 km (5.6 mi) wide between Cornwallis and Elephant Islands, in the South Shetland Islands of Antarctica. This strait was known to sealers as early as 1821, but the first record of its navigation was in 1839 by the brig Porpoise of the United States Exploring Expedition squadron under Wilkes. Soundings of the strait were made by the vessel John Biscoe and the frigate HMS Sparrow in December 1948. It was named for King Charles III, son of Queen Elizabeth II of the United Kingdom.

 This article incorporates public domain material from "Prince Charles Strait". Geographic Names Information System. United States Geological Survey. 

• UK Antarctic Place-names Committee: Map 13676: South Shetland Islands : Elephant, Clarence and Gibbs Islands, M 1 : 220 000, by: data.aad.gov.au, Australian Antarctic Data Centre

61°5′S 54°35′W / 61.083°S 54.583°W / -61.083; -54.583