Prince of Wales Secondary School is a public secondary school located in Vancouver, British Columbia, Canada.

Prince of Wales is named in honour of Edward, Prince of Wales, the heir apparent to the Canadian throne. The ostrich feather and crown symbol, and the Ich dien motto of the school are identical to those of its namesake. Prince of Wales opened for classes in September 1920 at its original site, which is now Shaughnessy Elementary School. In 1960 it moved to its current location, which had previously been a golf course.

Prince of Wales Mini School is a district mini school program of 140 students that seeks students from Vancouver who have demonstrated above average academic achievement and involvement in school and community. Each year, students attend outdoor education trips to strengthen the community and learn new skills.

Prince of Wales offers a variety of electives that appeal to student interests, which range from applied skills such as home economics, stagecraft, technical education, and business education, to fine arts (graphic design, filmmaking, photography, art, choir, music). Many students pursue these electives for personal interest, or they choose these courses because they will be studying in this fields for their post-secondary programs. For example, many students take senior level accounting, marketing, and economics courses offered at PW and go on to study Commerce / Business in their post-secondary program.

The TREK program is offered for grade 10 students from schools throughout the Vancouver School District with an interest in outdoor activities and environmental education.

The program admits 112 students each year, who are get to go on various outdoor trips throughout their school year. The program finishes most of the regular grade 10 academic curriculum while being able to participate in outdoor activities, including both overnight and day trips that teach basic outdoor skills, minimum impact camping, hiking and backpacking, ocean kayaking, canoeing, rock climbing, back-country (telemark) skiing, cross-country (Nordic) skiing, snow shelter building & winter camping, avalanche awareness, cycle touring, outdoor cooking, and map & compass navigation, and in-class focus on sustainability and the environment.

The Gifted Over Learning Disabled (GOLD) Program is a district program designed for gifted students who have also been identified as having a learning disability. The acceptance rate is very low with an average of only about 8 students per year. Students in the program have at least one GOLD block as part of their regular timetable with GOLD English also being offered at the grade 8 level. The curriculum of the program includes communication skills, decision making, subject and personal support, self-awareness and self-advocacy.

Prince of Wales formerly operated on a linear timetable of Day 1 / Day 2 rotation, from early September to late June. Each day has four (4) blocks with 80 minutes of instruction in each block. Classes begin at 8:40 a.m. and end at 3:05 p.m. during the 2023-2024 school year. Prince of Wales operates on a semester system. Classes are in session from 8:40 to 11:35 and 12:20 to 3:05 like other schools in the Vancouver School Board, with 4 classes every semester.

Prince of Wales sports teams are named Walesmen. Prince of Wales sports teams include Cross-country, Bantam Boys Rugby, Juvenile Boys Rugby, Bantam Girls Volleyball, Juv/Junior Girls Volleyball, Senior Girls Volleyball, Swimming, Girls Basketball, Bantam Girls Basketball, Juvenile Girls Basketball, Jr/Senior Girls Basketball, Boys Basketball, Bantam Boys Basketball, Juv/Junior Boys Basketball, Senior Boys Basketball, Grade 8/Juvenile Girls Soccer, Tennis, Gymnastics, Ultimate, Girls Softball, Track & Field, Junior Boys Rugby, Senior Boys Rugby, Badminton, and Golf as well as inter-mural sports, such as hand-ball. They are known for their table tennis. Walesmen reached the top 8 of Bantam Boys' Basketball for the second year in a row (21-22, 22-23).

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (November 2023)

• Kim Campbell, First female Prime Minister of Canada.
• Deborah Grey, First Reform Party member of Parliament.
• Spencer Chandra Herbert, first MLA for Vancouver West End, youngest elected Vancouver Park Commissioner.
• Emmanuelle Schick Garcia, film director/screenwriter.
• Bruce Fairbairn, music producer for Bon Jovi, Aerosmith, AC/DC, Loverboy, Van Halen, Chicago, The Cranberries and KISS.
• Lawrence Chou, Hong Kong actor, singer.
• Jessie Farrell, Canadian country music award-winning singer.
• Rafe Mair, broadcaster, political analyst.
• Andrea Neil, pioneer of women’s soccer in Canada and first woman to be inducted for soccer into Canada's Sport Hall of Fame.
• Peter New, actor, voice actor and screenwriter with roles in Agent Cody Banks, Diary of a Wimpy Kid and Antitrust.
• Nicholas Lea, actor best known for his portrayal of Alex Krycek from The X-Files and as star/producer of Whistler.
• Sara Neil, Olympic cyclist, winner of the bronze medal in the 57 km road race at the 1987 Pan American games.
• Jenny Pat, Hong Kong-born, Chinese-Canadian international art dealer, visual artist, and television personality.

• Tseng Kwong Chi, Hong Kong-born American Photographer, Artist.
• Peter Kelamis, Actor and Comedian.

• Monarchy in British Columbia
• Royal eponyms in Canada