Puybrun (French pronunciation: [pɥibʁœ̃]; Occitan: Puègbrun) is a commune in the Lot department in south-western France.

The toponym Puybrun (in Occitan Pègbrun) is found in the form Bastida de Podio bruni which is formed from Puy which is a francization of the Occitan pèg, pech from the Latin podium with the meaning of place located on a height and brown because of the colour given by the iron ore.

In 1282, a bastide was founded at Puybrun by Philipe de Hardi and William IV, a cistercian abbot of Dalon in the Perigord. A paréage had been created between the two in 1279. The bastide was not granted the right to build walls and ditches. The bastide would be attacked during the Hundred Years' War between the English and French and again during the French Wars of Religion in 1562 and again 1585.

• Église Saint-Blaise de Puybrun. Built in 1300s but rebuilt in between 1600 and 1620 as it was severely damaged during the Religious Wars.

• Charles Nuville (1889-1965), aviator, ace of the First World War, born in Puybrun.
• Jacky Lamothe, born in Puybrun in 1950, international basketball player.

• Communes of the Lot department