The Pyke River is a river in the south west of New Zealand's South Island. It flows generally south into Lake Wilmot then Lake Alabaster, before becoming a tributary of the Hollyford River.

The Pyke River begins at the confluence of the Sealy Stream and Trinity Creek in Mount Aspiring National Park, forming much of the park's western border in Southland District. The Pyke River begins to flow through Fiordland National Park after meeting the Olivine River.

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  The Demon Trail, a section of the Hollyford Track, involves a swing bridge crossing of the Pyke River.
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  Lake Alabaster is a prominent lake fed by the Pyke River.

• List of rivers of New Zealand