The Pylos Combat Agate is a Minoan sealstone of the Mycenaean era, likely manufactured in Late Minoan Crete. It depicts two warriors engaged in hand-to-hand combat, with a third warrior lying on the ground. It was discovered in the Griffin Warrior Tomb near the Palace of Nestor in Pylos and is dated to about 1450 BCE. The seal has come to be known as Pylos Combat Agate.

The seal is noted for its exceptionally fine and elaborate engraving, and considered "the single best work of glyptic art ever recovered from the Aegean Bronze Age". The quality of the work anticipates later developments as far ahead as the Classical era of a millennium later.

The Pylos Combat Agate was discovered by a University of Cincinnati archaeological team directed by Sharon Stocker and Jack Davis in the Griffin Warrior Tomb near modern-day Pylos. It consists of an amygdaloid (almond-shaped) sealstone of banded agate, with gold caps, measuring 3.6 cm in length (1.4 in) and was found alongside four gold signet rings.

Though the site was discovered in 2015, the agate, then covered in calcium carbonate encrustations, would not be revealed until 2017 as other finds from the site were published first. Afterwards, the agate underwent conservation and study for a year. Prior to conservation, the stone was believed to be a bead due to its small scale. Due to a longstanding consensus that Mycenaean civilizations imported or stole riches from Minoan Crete, it is believed that the seal was created in Crete. The fact that the stone was found in a Mycenaean tomb in mainland Greece is suggestive of cultural exchange between the Minoan and Mycenaean civilizations.

The seal portrays a warrior who, having already defeated one opponent sprawled at his feet, is plunging his sword into the exposed neck of another foe holding a "figure-of-eight" shield, while at the same time grabbing the crest of the man's helmet. The scene strikingly resembles the one depicted on the gold cushion seal from Shaft Grave III in Grave Circle A in Mycenae (and is similar to other Late Bronze Age signets or seals, such as the "Battle of the Glen" gold signet from the Shaft Grave IV at Mycenae). It is believed that all these objects were modeled after a well-known prototype, perhaps a wall painting, as it had already been suggested for other Early Mycenaean works of glyptic art; this view is partly shared by the discoverers, who otherwise see an intentional parallel between the winning hero in the sealstone and the person who was buried with it, also in view of the correspondence between his arms and ornaments (e.g., a necklace and a sealstone) and objects that are also found in the grave, close to the body.