President Elpidio Quirino Avenue, more commonly known as Quirino Avenue, is a 6-10 lane divided highway in Manila, Philippines. It runs for 3.6 kilometers (2.2 mi) in a northeast–southwest direction from Nagtahan Bridge (now Mabini Bridge) across Santa Mesa in the north to Roxas Boulevard in Malate in the south. It passes through the Paco and Pandacan districts and serves as a truck route between the Port Area and the South Luzon Expressway. North of Nagtahan Bridge, the road continues as Nagtahan Street. It is designated as part of Circumferential Road 2. It is named after Elpidio Quirino, the sixth President of the Philippines.

Nagtahan Bridge to Paco-Santa Mesa Road section

The northern end of Quirino Avenue is at the intersection of Paz Mendoza Guazon (Otis) and Jesus Streets in Paco, at the foot of the Nagtahan Bridge, as a continuation of Nagtahan Street. Heading south, it enters Pandacan, moving past primarily residential areas on both sides, meeting the Nagtahan ramps to and from Skyway Stage 3, and passing by Zamora Market on the western side. At Plaza Berde, the avenue then curves southwest to follow the alignment of the Philippine National Railways line, which merges with traffic from Paco-Santa Mesa Road (Tomas Claudio Street).

Paco-Santa Mesa Road to Osmeña Highway section

South of the junction with Tomas Claudio, the avenue re-enters the district of Paco, where the old Paco station and Plaza Dilao are located. Southbound traffic is currently carried by Plaza Dilao Road, a loop road around Plaza Dilao just off the main highway, while northbound traffic remains on Quirino. Also located along this stretch are the Plaza Dilao on-ramp to Skyway, the Philippine Columbian Association complex on Plaza Dilao, and the new Paco railway station near the intersection with Pedro Gil Street. It follows a straight path south towards the border with Malate and is joined by Osmeña Highway.

Osmeña Highway to Roxas Boulevard section

The Malate section of Quirino Avenue is primarily residential and commercial. The Singalong area, where the Quirino ramps to and from Skyway are located, lies directly south of the Osmeña Highway junction just before it intersects with Taft Avenue, where the elevated Quirino LRT Station is located. Past Taft Avenue, Quirino Avenue provides access to the tourism center of Malate. It curves westwards past Adriatico Street until it meets its southern terminus at Roxas Boulevard, overlooking Manila Bay. A monument of Elpidio Quirino, after whom the avenue is named, is also located at the intersection.

Quirino Avenue Extension

Quirino Avenue Extension looking south towards Plaza Dilao
Former name(s)	Calle Canonigo
Namesake	Elpidio Quirino
Length	0.75 km (0.47 mi) Approximate length
Location	Paco, Manila
North end	N156 (United Nations Avenue) / Paz Mendoza Guazon Street / Cristobal Street
South end	N156 (Plaza Dilao Road)

Quirino Avenue extends to the industrial area of Paco (Otis) and United Nations Avenue from Plaza Dilao Road. Formerly known as Calle Canonigo, this is the main truck route going in and out of the Port Area from Osmeña Highway.

The avenue's origin dates back to the early 19th century under Spanish colonial rule when the avenue was first laid out as Calle Canonigo in Paco. The road to Nagtahan Bridge was a narrow street called Calle Luengo in Pandacan. The narrow street connecting southern Malate to Cavite Boulevard (now Roxas Boulevard) was called Calle Cortabitarte.

Built in the 20th century, the avenue was initially known as Dewey Boulevard (for being an erstwhile continuation and a part of the present-day Roxas Boulevard) and as Harrison Boulevard. It was renamed Koa Boulevard during World War II and Japanese occupation in 1942. The whole length of the highway that forms part of Circumferential Road 2 was later named in honor of the sixth President of the Philippines, Elpidio Quirino.

• Aloha Hotel
• Asociacion de Damas de Filipinas
• Bureau of Plant Industry
• Jacinto Zamora Elementary School
• Manila Zoo
• Old Paco railway station
• Ospital ng Maynila Medical Center
• Malacañang Hospital
• Manuel Roxas High School
• Paraiso ng Batang Maynila Park
• Philippine Columbian Association
• Plaza Dilao
• President Elpidio Quirino Monument
• Saint Peter the Apostle School
• San Andres Market
• Zamora Market

The entire route is located in Manila. Intersections are numbered by kilometer post, with Rizal Park, also in Manila, designated as kilometer 0. 

km	mi	Destinations	Notes
		N140 (Nagtahan Bridge), Paz Mendoza Guazon Street, Jesus Street	Northern terminus; continues north as Nagtahan Bridge
		Mendoza Guazon Street	Southbound only
5.700	3.542	P. Quirino Bridge 3 over Estero de Pandacan
		Skyway	Skyway-Nagtahan Exit; northbound entrance from Skyway Stage 3
		East Zamora Street	Northbound entrace only
		Paradise Street	Northbound only
		Skyway	Skyway-Nagtahan Exit; southbound exit to Skyway Stage 3 northbound
		Obisis Street	Southbound only
		Carlos Street Extension	Northbound only
		West Zamora Street	Former traffic light intersection
		San Jose Street	Northbound only
		E. Carlos Street	Northbound only
		N141 (Tomas Claudio Street)	Northbound only
4.450	2.765	P. Quirino Bridge 2 over Estero de Pandacan
		Skyway	Skyway-Plaza Dilao Exit; southbound exit
		N156 (Plaza Dilao Road)	Northbound exit, southbound exit, and southbound entrance only
		Santo Sepulcro Street	Southbound only.
		Figueroa Street	One-way; no entry from Quirino Avenue
		Pedro Gil Street	Traffic light intersection; no right turn allowed from southbound and no left turn allowed from northbound
		Sagat Street	One-way; southbound only
		N145 (Osmeña Highway)	Traffic light intersection.
		Union Street, Lanuza Street	Southbound only; Union Street is one-way
		Paz Street	Southbound only
3.850	2.392	P. Quirino Bridge 1 over Estero de Paco
		Anak Bayan Street, Julio Nakpil Street, Mataas na Lupa Street	Unsignalized intersections.
		Campillo Street	Northbound only
		Angel Linao Street	Unsignalized intersection; one-way road and former traffic light intersection
		Pintong Bato Street	Southbound only
		Smith Street	Northbound only
		Skyway	Skyway-Quirino Exit; northbound exit and southbound entrance
		Singalong Street	One-way road and former traffic light intersection; no access to opposite direction.
		San Bartolome Street	Limited access road; southbound only
		F. Benitez Street	One-way road; no access to opposite direction
		Modesto Street	No access to opposite directions
		N181 (San Marcelino Street)	Traffic light intersection; one-way road
		San Pascual Street, Agoncillo Street	No access to opposite directions
		San Antonio Street	Northbound only
		Leon Guinto Street	Traffic light intersection
		San Andres Street	One-way road going in opposite directions; bisected by Taft Avenue
		N170 (Taft Avenue)	Traffic light intersection
		Fidel A. Reyes Street, Maginhawa Street, Bagong Lipunan Street	Northbound only
		Leveriza Street	Traffic light intersection
		Camia Street, Asuncion Street	Northbound only
		Adriatico Street	Traffic light intersection; northern segment is one-way towards Manila Zoological and Botanical Garden
		Madre Ignacia Street	Unsignaled intersection
		Mabini Street	Traffic light intersection; northern segment is one-way only
		Del Pilar Street	Traffic light intersection; one-way entrance only
		AH 26 (N120) (Roxas Boulevard)	Southern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Incomplete access

The entire route is located in Manila. 

km	mi	Destinations	Notes
		N156 (Plaza Dilao Road)	Southern terminus
		San Antonio Street	One-way entrance only
		San Gregorio Street	Southbound only
		Peñafrancia Street, Zamora Street	Traffic light intersection
		Peñafrancia Extension	Northbound only
		Zulueta Street	Southbound only
		Paz Street	Unsignalled intersection
		Cristobal Street	Southbound entrance only
		N156 (United Nations Avenue), Paz Mendoza Guazon Street	Northern terminus; traffic light intersection
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Incomplete access

• Major roads in Manila

14°34′33″N 120°59′46″E / 14.57583°N 120.99611°E / 14.57583; 120.99611