Rapoltu Mare (Hungarian: Nagyrápolt, German: Groß-Rapolden) is a commune in Hunedoara County, Transylvania, Romania. It is composed of five villages: Bobâlna (Bábolna), Boiu (Boj), Folt (Folt), Rapoltu Mare and Rapolțel (Kisrápolt).

The Hungarian noble family Szent-Györgyi de Nagyrápolt has used the name of this village since the Middle Ages. Its most famous member is the scientist Albert Szent-Györgyi.

• Atanasie Anghel (died 1713), Romanian Greek-Catholic bishop of Alba Iulia between 1698 and 1713
• József Somkuthy (1883–1961), Hungarian military officer and politician