Rheinhessen-Pfalz (rarely anglicized as "Rhine-Hesse-Palatinate") was one of the three Regierungsbezirke of Rhineland-Palatinate, Germany, located in the south of the state. It was created in 1968 out of Regierungsbezirke Rheinhessen and Pfalz, which had themselves been created out of the left-bank territories of Bavaria and Hesse-Darmstadt before World War II.

Since 2000, the employees and assets of the Bezirksregierungen form the Aufsichts- und Dienstleistungsdirektion Trier (Supervisory and Service Directorate Trier) and the Struktur- und Genehmigungsdirektionen (Structural and Approval Directorates) Nord in Koblenz and Süd in Neustadt (Weinstraße). These administrations execute their authority over the whole state, e.g. the ADD Trier oversees all schools.