Route 110 is a numbered state highway running 6.1 miles (9.8 km) wholly within the town of South Kingstown in Rhode Island. It serves to connect the University of Rhode Island to points south via U.S. Route 1 (US 1).

Route 110 begins at US 1 near the village of Perryville in South Kingstown. The route heads north for 7 miles (11 km) following Ministerial Road through the wetlands of the Great Swamp. Along the way it intersects with the William C. O'Neill Bike Path. Soon after crossing some railroad tracks, Route 110 ends at an intersection with Route 138 in the village of West Kingston.

Route 110 was assigned to Ministerial Road by 1969.

The entire route is in Washington County.

Location	mi	km	Destinations	Notes
South Kingstown	0.0	0.0	US 1 south (Commodore Perry Highway)	Southern terminus, northbound access via nearby U-turn ramps
	0.2	0.32	Route 1A (Post Road)
West Kingston	6.1	9.8	Route 138 (Kingstown Road)	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• 2019 Highway Map, Rhode Island