The River to River Trail is a 160 mile (256 km)-long hiking trail that serves Shawnee National Forest in far southern Illinois. The trail is used by both equestrians and hikers. About half is on off-road trails. Its eastern terminus has historically been Battery Rock, overlooking the Ohio River but now generally Elizabethtown, Illinois is used as the eastern terminus. The western terminus is in Grand Tower, Illinois, at the Mississippi River. Sections of the River to River Trail form part of the Southern Section of the American Discovery Trail.

From east to west, the trail serves the following settlements and resources:

• Elizabethtown, Illinois
• Garden of the Gods Wilderness
• One Horse Gap
• Lusk Creek Wilderness
• Eddyville, Illinois
• Jackson Falls climbing area
• Tunnel Hill State Trail
• Ferne Clyffe State Park
• Panther Den Wilderness
• Crab Orchard Wilderness
• Giant City State Park
• Makanda, Illinois
• Bald Knob Wilderness
• Clear Springs Wilderness
• Grand Tower, Illinois

The River to River Trail Society has published a guidebook to the trail's campsites, orientation, safe water sources, and other useful information. A significant spur trail serves Elizabethtown, Illinois.

Following are waypoints on the trail:

Waypoint	Coordinates
Battery Rock	37°31′45″N 88°04′47″W / 37.529179°N 88.079796°W / 37.529179; -88.079796 (River to River Trail Waypoint Battery Rock)
IL 1	37°33′19″N 88°10′31″W / 37.5551929°N 88.17519660000001°W / 37.5551929; -88.17519660000001 (River to River Trail Waypoint IL 1)
Elizabethtown	37°26′45″N 88°18′23″W / 37.445895°N 88.306437°W / 37.445895; -88.306437 (River to River Trail Waypoint Elizabethtown)
County 12	37°29′50″N 88°19′26″W / 37.4971416°N 88.3237693°W / 37.4971416; -88.3237693 (River to River Trail Waypoint County 12)
Junction E'Town & Battery Rock	37°35′36″N 88°18′22″W / 37.593285°N 88.306065°W / 37.593285; -88.306065 (River to River Trail Waypoint Junction E'Town & Battery Rock)
Garden of the Gods State Park	37°36′09″N 88°23′02″W / 37.60251°N 88.38383°W / 37.60251; -88.38383 (River to River Trail Waypoint Garden of the Gods State Park)
Herod	37°34′49″N 88°26′11″W / 37.580397°N 88.436514°W / 37.580397; -88.436514 (River to River Trail Waypoint Herod)
One Horse Gap	37°31′03″N 88°27′31″W / 37.5175765°N 88.4586793°W / 37.5175765; -88.4586793 (River to River Trail Waypoint One Horse Gap)
Lusk Creek	37°31′31″N 88°33′01″W / 37.5252477°N 88.5502338°W / 37.5252477; -88.5502338 (River to River Trail Waypoint Lusk Creek)
Eddyville	37°30′03″N 88°35′11″W / 37.500951°N 88.586344°W / 37.500951; -88.586344 (River to River Trail Waypoint Eddyville)
Bay Creek / Millstone Bluff	37°29′02″N 88°41′29″W / 37.4839511°N 88.6912537°W / 37.4839511; -88.6912537 (River to River Trail Waypoint Bay Creek / Millstone Bluff)
US 45	37°29′14″N 88°50′34″W / 37.48722°N 88.842831°W / 37.48722; -88.842831 (River to River Trail Waypoint US 45)
Tunnel Hill State Trail	37°29′37″N 88°52′16″W / 37.4935198°N 88.8712245°W / 37.4935198; -88.8712245 (River to River Trail Waypoint Tunnel Hill State Trail)
Interstate 24	37°29′26″N 88°53′41″W / 37.490626°N 88.894672°W / 37.490626; -88.894672 (River to River Trail Waypoint Interstate 24)
Gould Lake	37°28′52″N 88°56′41″W / 37.481022°N 88.944722°W / 37.481022; -88.944722 (River to River Trail Waypoint Gould Lake)
IL 37	37°31′29″N 88°57′56″W / 37.524609°N 88.96552300000001°W / 37.524609; -88.96552300000001 (River to River Trail Waypoint IL 37)
Goreville / Ferne Cliffe	37°32′55″N 88°58′45″W / 37.548737°N 88.97928°W / 37.548737; -88.97928 (River to River Trail Waypoint Goreville / Ferne Cliffe)
Interstate 57	37°33′21″N 89°01′58″W / 37.555899°N 89.032752°W / 37.555899; -89.032752 (River to River Trail Waypoint Interstate 57)
Panther Den Wilderness	37°34′58″N 89°05′17″W / 37.5828136°N 89.0880703°W / 37.5828136; -89.0880703 (River to River Trail Waypoint Panther Den)
Giant City State Park	37°35′32″N 89°10′58″W / 37.592148°N 89.182913°W / 37.592148; -89.182913 (River to River Trail Waypoint Giant City State Park)
Makanda	37°37′04″N 89°12′34″W / 37.617656°N 89.209306°W / 37.617656; -89.209306 (River to River Trail Waypoint Makanda)
US 51	37°36′38″N 89°14′01″W / 37.610577°N 89.233682°W / 37.610577; -89.233682 (River to River Trail Waypoint US 51)
Cedar Lake	37°36′46″N 89°17′21″W / 37.612773°N 89.28925200000002°W / 37.612773; -89.28925200000002 (River to River Trail Waypoint Cedar Lake)
Alto Pass	37°34′13″N 89°19′04″W / 37.570255°N 89.317667°W / 37.570255; -89.317667 (River to River Trail Waypoint Alto Pass)
Bald Knob Wilderness	37°34′08″N 89°21′41″W / 37.56891°N 89.3614709°W / 37.56891; -89.3614709 (River to River Trail Waypoint Bald Knob Wilderness)
Clear Springs Wilderness	37°35′27″N 89°26′22″W / 37.59072°N 89.43950400000001°W / 37.59072; -89.43950400000001 (River to River Trail Waypoint Clear Springs Wilderness)
Big Muddy River / IL 3	37°33′43″N 89°28′19″W / 37.56204°N 89.471884°W / 37.56204; -89.471884 (River to River Trail Waypoint Big Muddy River / IL 3)
Devils Backbone Park / Grand Tower	37°38′20″N 89°30′39″W / 37.638924°N 89.51086100000001°W / 37.638924; -89.51086100000001 (River to River Trail Waypoint Devils Backbone Park / Grand Tower)

• River to River Trail Society
• Hiking Project Downloadable gpx from 2017.
• Full trail on OpenStreetmap.org
• Full trail downloadable GPX at Way Marked Trails
• Trail Journals for River to River Trail
• Trail Run Project