The Diocese of Santa Clara is a diocese of the Latin Church of the Roman Catholic Church in Cuba. The diocese is a suffragan of the Archdiocese of Camagüey. Originally erected as part of the Diocese of Cienfuegos in 1903, the parent diocese was renamed to the Diocese of Cienfuegos-Santa Clara in 1971. Finally in 1995 the parent diocese was split to form the Diocese of Cienfuegos and the Diocese of Santa Clara.

• Fernando Ramon Prego Casal (1995 – 1999)
• Marcelo Arturo González Amador (1999 – present)

• Marcelo Arturo González Amador (1998-1999), appointed Bishop here

• "Diocese of Santa Clara". Catholic-Hierarchy. Retrieved 2007-02-12.

22°24′22″N 79°58′05″W / 22.4062°N 79.9680°W / 22.4062; -79.9680