Roosevelt Avenue and Greenpoint Avenue are main thoroughfares in the New York City boroughs of Queens and Brooklyn. Roosevelt Avenue begins at 48th Street and Queens Boulevard in the neighborhood of Sunnyside. West of Queens Boulevard, the road is named Greenpoint Avenue and continues through Sunnyside and Long Island City across the Greenpoint Avenue Bridge into the borough of Brooklyn, terminating at WNYC Transmitter Park on the East River in the neighborhood of Greenpoint. Roosevelt Avenue goes through Woodside, Jackson Heights, Elmhurst, Corona, Flushing Meadows–Corona Park (adjacent to Citi Field) and Flushing. In Flushing, Roosevelt Avenue ends at 156th Street and Northern Boulevard.

Roosevelt Avenue was nationally recognized for its cuisine when Good Magazine named it one of "America's Tastiest Streets". It’s also well known for its diversity of cultural representation, ranging from Indian to Latin American, while in the 2020s, Downtown Flushing is undergoing rapid gentrification by Chinese transnational entities. More than three hundred languages are spoken along the street, and the neighborhoods it passes through are described as the most ethnically diverse in the world.

Structures along the avenues include Eberhard Faber Pencil Factory on the western end of Greenpoint Avenue and the Newtown Creek Wastewater Treatment Plant just west of the Greenpoint Avenue Bridge. The eastern end of Roosevelt Avenue contains the Protestant Reformed Dutch Church of Flushing.

The corridor is served by the following subway lines:

• The 7 and <7>​ trains run on the elevated IRT Flushing Line tracks above the street with ten stations until it reaches Flushing – Main Street, its eastern terminus. The rail line opened in 1917, when Roosevelt Avenue was formed from the combination of other streets into one main avenue.
• The street, itself named after Theodore Roosevelt and Franklin D. Roosevelt, provides the name for the Roosevelt Avenue / 74th Street station (7, <7>​​, E, ​F, <F>, ​M, and ​R trains) in Jackson Heights.
• The G train stops at the Greenpoint Avenue station located at Greenpoint Avenue and Manhattan Avenue.

The following bus routes serve Roosevelt:

• The Q32 runs between Queens Boulevard and either 81st Street (Jackson Heights), or 82nd Street (Midtown, Manhattan).
• The Q48 runs between 108th and Main Streets. Flushing service heads west on Roosevelt non-stop from Union Street to Main Street before switching to LaGuardia Airport.
• The Q53 runs between Broadway and 61st Street, where it terminates.
• The Q47 runs between 69th Street and either 74th Street (LaGuardia Airport), or 75th Street (Glendale).
• The Q33 runs between Broadway and either 82nd Street (Jackson Heights), or 83rd Street (East Elmhurst).
• Most Q29 buses run from 83rd Street to 82nd Street, where it terminates.
• The East Elmhurst-bound Q49 runs from Broadway to 74th Street.
• The Q12, Q15 and Q26 run between Bowne and Union Streets. In addition, Main Street is a drop-off stop for the Q26 to Flushing, and a pick-up stop for the Q15 to Beechhurst.
• The Nassau-bound n20G runs from Bowne Street to Main Street.
• The westbound Q19 and Q66 buses run from Prince Street to Main Street, where service originates.

The B24 is the only bus route to serve Greenpoint Avenue, from 47th Street to West Street (Greenpoint), and from Manhattan Avenue to 48th Street (Williamsburg). Greenpoint service runs east on the avenue non-stop from Franklin Street to Manhattan Avenue before switching to Williamsburg.