The Round Rock Commercial Historic District is an historic district in Round Rock, Texas, listed on the National Register of Historic Places.

The district has 22 contributing structures, including:

• 100 East Main Street (1880): Shuey's Furniture Store; Old Broom Factory, a two-story limestone building
• 101 East Main Street (1876): Kopperal's General Store (Fabric Designs), a one-story, stone-masonry building
• 102 East Main Street (1879): Otto Reinke Building (Round Rock Travel and Tours, and Round Rock Leader), a two-story building
• 103 East Main Street (1876): Miller's Exchange Bank (Earl's Brushy Creek Gallery), a one-story, stone-masonry building
• 104 East Main Street (1947): Round Rock Insurance and John's Barber Shop
• 105 East Main Street (1876): Sam Bass General Store, a one-story building
• 109 East Main Street (1885): Maschall and McNeary, Attorneys, a one-story, stone-masonry building
• 111 East Main Street (1916–1925): Round Rock Printing, a brick building
• 112 East Main Street (1881)
• 114 East Main Street (1881): Bo-Kay Florist
• 115 East Main Street (1885): Gus's Drug Store, a one-story, stone-masonry building
• 116 East Main Street (1880): Round Rock Professional Building
• 117 East Main Street (1891): The Fair, a one-story, stone-masonry building
• 118 East Main Street (1880): First National Bank
• 118 East Main Street (1880): First National Bank
• 119 East Main Street (1881): Robertson's Gift Shop, a one-story, stone-masonry building
• 121 East Main Street (1877): Voight and Brady Grocery; also, W.J. Walsh General Merchandise (Kelly's Cleaners)
• 200 East Main Street (1902–1909): Anderson-Nelson Company (Photocopy & Mike Faulk and Associates, Architects)
• 203 East Main Street (1900): Nelson Hardware; "The Co-op", a two-story limestone building
• 204 East Main Street (1902–1909): Economy Drug Store (Quick Pharmacy)
• 206 East Main Street (1930s): Dr. Gregg's Office
• 208 East Main Street (1873): Andrew J. Palm House (Round Rock Chamber of Commerce)
• 107 South Mays Street (1878): Old Post Office Building (Masonic Lodge #227), a two-story building

Additionally, there are three non-contributing properties:

• 108 and 110 East Main Street (1880)
• 113 East Main Street (c. 1920): Round Rock of Music

• National Register of Historic Places listings in Williamson County, Texas

• Media related to Round Rock Commercial Historic District at Wikimedia Commons