Route 142 is a highway in southern Missouri. Its eastern terminus is at Route 53 in southern Poplar Bluff; its western terminus is at Route 101 in Bakersfield. Route 142 is the southernmost east–west highway in the south-central part of the state. Despite its length, there are relatively few towns on the route.

County	Location	mi	km	Destinations	Notes
Ozark	Bakersfield	0.000	0.000	Route 101
		0.040	0.064	Route AR to AR 87
Howell	Lanton	20.811	33.492	Route 17 – Arkansas state line, West Plains
Oregon	Thayer	36.010	57.952	US 63 Bus. north	Western end of US 63 Business overlap
		36.472	58.696	US 63 south – Mammoth Spring US 63 Bus. ends	Eastern end of US 63 Business overlap; western end of US 63 overlap
		37.105	59.715	US 63 north – West Plains	Eastern end of US 63 overlap
Ripley	West Doniphan Township	78.768	126.765	Route 21 south – Pocahontas	Western end of Route 21 overlap
		80.015	128.772	US 160 west – Alton	Western end of US 160 overlap
	Doniphan	81.904	131.812	US 160 east / Route 21 north / Route Y	Eastern end of US 160 and Route 21 overlaps
Butler	Neelyville	103.147	165.999	US 67 – Corning, Poplar Bluff
	Coon Island Township	109.200	175.740	Route HH	Route 142 changes from an east–west to north–south orientation
	Poplar Bluff Township	116.700	187.810	Route 158 west – Harvell
		122.328	196.868	Route 53 to US 67 Bus. / Route WW
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus