Route 161 is a highway in northeastern Missouri. Its northern terminus is at Business U.S. Route 61 in Bowling Green; its southern terminus is at Interstate 70/U.S. Route 40 south of Montgomery City.

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Missouri Route 161 was formerly known as Route 29.

This section is empty. You can help by adding to it. (May 2021)

County	Location	mi	km	Destinations	Notes
Montgomery	Danville	0.000	0.000	Route J	Continuation past I-70
		0.000– 0.115	0.000– 0.185	I-70 / US 40	Exit 170 along I-70
	Montgomery City	6.044	9.727	Route 19 south (Sturgeon Street)	Southern end of Route 19 overlap
		6.119	9.848	Route 19 north (Sturgeon Street)	Northern end of Route 19 overlap
Pike	Bowling Green	41.200	66.305	US 61 Bus. north	Southern end of US 61 Business overlap
		42.092– 42.299	67.741– 68.074	US 61 (Avenue of the Saints) / US 61 Bus. ends	Interchange; northern end of US 61 Business overlap
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus