Ruffano (Salentino: Rufanu) is a town and comune in the province of Lecce, located in the Apulia region of southeast Italy.

• Mother church of Natività della Beata Maria Vergine (1706–1713)
• Church of Madonna del Carmine, built in the 16th century above a Byzantine cave church from the 12th century
• Castello Brancaccio, a castle overlooking the town (1626)
• Crucifix Crypt, near the boundary with Casarano
• Grotta della Trinità ("Trinity Grotto"), used since Neolithic times. Starting from the 9th century, it housed a community of hermit monks and in the 11th century, it was turned into a religious place, as testified by remains of Byzantine frescoes.