Running Creek is a stream in the municipality of Chatham-Kent in Southwestern Ontario, Canada. It is a left distributary of the Chenail Ecarté (The Snye), is a tributary of the North Sydenham River, and is part of the Great Lakes Basin.

The creek begins at the Chenail Ecarté (The Snye) at an elevation of 175 metres (574 ft), and flows east to its mouth at the North Sydenham River, at an elevation of 175 metres (574 ft), on the north side of the community of Wallaceburg. The North Sydenham River flows via the Sydenham River, Lake St. Clair and the Detroit River to Lake Erie.