Sédhiou (Wolof: Seéju) is a town of Senegal, in Casamance area, nearby the Casamance river, with a population of 31,511 in 2023. It is the capital of the Sédhiou Region.

The main historical culture of Sédhiou came from the Mandinka people, but many populations are located in the area nowadays. It was the center of one of the constituent kingdoms of the Kaabu Federation.

In 1861 Sedhiou became the seat of one of the first seven arrondissements of the French colony of Senegal. In 1876 the marabout Fode Kaba raided the Balanta villages nearby, but was forced to withdraw by the French forces stationed in the town. His ally Sounkari, the chief of Bacoum, nevertheless continued the fight and unsuccessfully besieged the French fort in 1882. He was eventually defeated by Alfred Dodds in 1887.

Sedhiou was the capital of colonial Casamance from 1883 to 1906, when it moved to Ziguinchor. The commune of Sedhiou is created in February 1960.

It is the capital of the Sédhiou Region.

In 1983, 13,212 inhabitants lived in the town, rising to 18,465 in 2002. At the 2013 census Sédhiou had a population of 24,213.

• Sadio Mané (born 1992), professional footballer who plays for Saudi Pro League club Al Nassr FC and the Senegal national team.

• Les Ulis

• (in French) City web site
• (in French) Présentation of Sédhiou on Les Ulis official web site

12°42′N 15°33′W / 12.700°N 15.550°W / 12.700; -15.550