The Church of St. Anthony of Padua (Turkish: Sent Antuan Kilisesi), alternatively known as Sant'Antonio di Padova Church or S. Antonio di Padova, is the largest Catholic church in Istanbul, Turkey. It is located on İstiklal Avenue in the Beyoğlu district.

Together with the churches of St. Mary Draperis (also on Istiklal Avenue), and of SS. Peter and Paul in Galata, it was one of three Levantine parishes in Beyoglu. Today it is run by Italian priests. Saturday Mass in English begins at 19:00; Sunday Mass in Italian is at 11:30, in Polish at 11:30 in the crypt, in English at 10:00 and at 19:00 in Turkish; and Tuesday Mass in Turkish begins at 11:00. Weekday Masses are in English at 8:00 and in Turkish at 19:00.

The original Church of St. Anthony of Padua was built in 1725 by the Italian community of Istanbul, but was later demolished and replaced with the current building which was constructed on the same site. The current basilican church, along with the adjacent residential buildings (known as the St. Antoine Apartmanları) was built between 1906 and 1912 in Venetian Neo-Gothic style, again by the city's Italian community (mostly made up of people of Genoese and Venetian descent, the community amounted to about 40,000 at the start of the 20th century). The building was designed by the Levantine architect Giulio Mongeri, who also designed other important buildings in Turkey, such as the Maçka Palas in Nişantaşı and the Neo-Byzantine Karaköy Palas bank building in Karaköy (Galata), Istanbul, as well as the first headquarters of the Türkiye İş Bankası in Ankara.

Pope John XXIII preached here for 10 years while he was the Vatican's ambassador to Turkey before being chosen as pope. He is known as "the Turkish Pope" because of his fluency in Turkish and his oft-expressed love for Turkey and for Istanbul in particular. A statue of him is installed in the church's courtyard.

Since 2016 a legal battle has raged over the church which has been put up for sale by a man claiming to act for the site's legal owner. According to news reports, Sebahattin Gök obtained a power of attorney from the owners of the land and then attempted to sell it before lawyers acting on behalf of the Vatican took steps to prevent the sale.

St. Anthony of Padua may be the most important Roman Catholic church in Istanbul, and with the largest congregation, but there are other Roman Catholic churches in the city too. These include the Cathedral of the Holy Spirit (1846) in Harbiye; St. Louis of the French (1581) and Santa Maria Draperis in Beyoğlu; Sts. Peter and Paul (1841) in Galata; the Church of the Assumption in Moda, Kadıköy; and St. Stephen in Yeşilköy.

• 
  Church of St. Anthony of Padua
• 
  Church of St. Anthony of Padua front of complex
• 
  Apartments in front of Church of St. Anthony of Padua
• 
  Church of St. Anthony of Padua interior
• 
  Church of St. Anthony of Padua interior
• 
  Church of St. Anthony of Padua interior
• 
  West end of Church of St. Anthony of Padua
• 
  Statue of Pope John XXIII

• Levantines (Latin Christians)

• "Sent Antuan Kilisesi" [Church of St. Antony] (in Turkish). Retrieved 5 June 2010.

• Some more pictures
• "Church of St. Antony". on katolik kilisesi.

41°01′57″N 28°58′35″E / 41.0325°N 28.9764°E / 41.0325; 28.9764