State Route 22 (SR-22) is a state highway in southern Utah, running for 6.852 miles (11.027 km) in Garfield and Piute Counties from Antimony to Otter Creek Reservoir.

SR-22 begins in Antimony as a continuation of John's Valley Road and heads generally north through a canyon to Otter Creek Reservoir and Otter Creek State Park, where it ends at an intersection with SR-62.

The road from Widtsoe north to Antimony became a state highway in 1914, and in 1915 it was extended west to SR-11 (by 1926 US-89) in Junction. A forest road from Widtsoe south to SR-12 at Tropic Junction was added to the system in 1923, and in 1927 the legislature designated the entire route from Junction to Tropic Junction as SR-22. To improve route continuity on a shortcut between California and Colorado that included the portion of SR-22 between US-89 and SR-62 at Otter Creek Junction, that part was transferred to SR-62 in 1967. (With the completion of I-70 through the San Rafael Swell in 1970, this is no longer a popular route.) The legislature removed John's Valley Road from the state highway system in 1969, turning SR-22 into a short spur from SR-62 to the bridge over Antimony Creek just south of Antimony.

County	Location	mi	km	Destinations	Notes
Garfield	Antimony	0.000	0.000	John's Valley Road	Southern terminus
Piute	Otter Creek Junction	6.852	11.027	SR-62 – Junction, Koosharem	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi