Saddleback High School is a six-year IB secondary school located in Santa Ana, California, United States, and is part of the Santa Ana Unified School District. The school was established in 1967. Its mascot is the roadrunner, and its colors are green, gold, and white.

The school principal from 2009 to June 2015 was Dr. Robert Laxton. The current principal is Edward Bustamante.

Saddleback High School has adopted the nickname "The College Majors School".

The first CIF Champions in school history was under the leadership of Coach Jim Knapp (Track and Field), in 1973. The track athletes were all sophomores, John Peterson, Scott Brooklyn, Danny Ruvolo, and Sammy Murrietta

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (September 2015)

• Daniel Arreola - sportscaster for Fox Sports International
• David Bernal - dancer, performed "Robot Dance" at the 2001 Kollaboration competition
• Danny Lee Clark - voice and film actor, gladiator turned host of American Gladiators
• Jere Fields - film and television actress
• Tony Guerrero - jazz musician, composer, producer and writer
• Henry Hate - celebrity tattoo artist and visual artist
• Rishard Matthews - wide receiver, Miami Dolphins, Tennessee Titans, 2012–2019
• Erasmo Ramirez - professional baseball player
• Carlos Rincon - film executive, producer, agent
• Ronny Rios - Mexican-American professional boxer in the Super Featherweight division
• Terry Rossio - screenwriter and film producer, Shrek and Pirates of the Caribbean: The Curse of the Black Pearl
• Eddie "Piolín" Sotelo - Spanish-media radio host, KSCA FM

• Saddleback High School website