Saint-Adrien-d'Irlande is a municipality in the Municipalité régionale de comté des Appalaches in Quebec, Canada. It is part of the Chaudière-Appalaches region and the population is 415 as of 2009.

Until 1982, Saint-Adrien-d'Irlande was known as Ireland-Partie-Nord, to differentiate from the south part, today's Irlande. Then it took the name of the parish, which was named after Pope Adrian III.