Saint-Antoine-de-Tilly (French pronunciation: [sɛ̃t‿ɑ̃twan də tiji]) is a municipality in the Lotbinière Regional County Municipality in Quebec, Canada. It is part of the Chaudière-Appalaches region and had a population is 1,682 as of 2021.

A member of the Most Beautiful Villages of Quebec, Saint-Antoine-de-Tilly has been colonized since the early beginnings of New France. The seigneurie of Villieu was sold in 1700 to Pierre-Noël Le Gardeur de Tilly and became the seigneurie of Tilly, which is still part of the municipality's name.

Saint-Antoine is named in honour of St. Anthony of Padua.

In 1672, The territory of Saint-Antoine-de-Tilly was given to a lieutenant of the Carignan regiment, Claude-Sébastien de Villieu, by the intendant Jean Talon. Later, The territory was sold to Pierre-Noël Le Gardeur, sieur de Tilly. Under is ownership, in 1702, a parish was canonically erected and the territory took the name Saint-Antoine-de-Tilly. In 1759, the territory is the site of a battle during the conquest of New France.

The municipality was officially created in 1855. In 1909, it lost a small section of its territory for the creation of Notre-Dame-du-Sacré-Cœur-d’Issoudun. Finally, in 1995, the status of Saint-Antoine-de-Tilly was changed from a parish municipality to a regular municipality.

• Commission de toponymie du Québec
• Ministère des Affaires municipales, des Régions et de l'Occupation du territoire