Saint-Côme–Linière (French pronunciation: [sɛ̃ kom linjɛʁ]) is a municipality in the Beauce-Sartigan Regional County Municipality in the Chaudière-Appalaches region of Quebec, Canada. The official spelling given by the Commission de toponymie uses an en dash after "Saint-Côme", but the town's own website uses a second hyphen: Saint-Côme-Linière. The population is 3,278 as of 2021.

Saint-Côme–Linière was constituted by the amalgamation of the parish municipality of Saint-Côme-de-Kennebec and the village of Linière on August 17, 1994. Saint-Côme was named after Arabian-born Christian martyr Saint Cosmas and Linière received its name from the seigneur who was first granted the land and cultivated fields of flax ("Lin" in French).

Population trend:

Census	Population	Change (%)
2021	3,278	1.2%
2016	3,239	1.1%
2011	3,274	0.4%
2006	3,260	0.6%
2001	3,239	0.1%
1996	3,241	65.5%
1991	1,958	23.7%
1986	1,583	6.8%
1981	1,699	22.8%
1976	1,384	0.9%
1971	1,372	25.0%
1966	1,829	13.3%
1961	1,615	1.9%
1956	1,646	8.6%
1951	1,515	0.3%
1941	1,511	23.9%
1931	1,220	6.9%
1921	1,141	34.7%
1911	1,747	30.5%
1901	1,339	N/A%

Gabriel Giguère, mayor