Saint-Jean-de-Losne (French pronunciation: [sɛ̃ ʒɑ̃ də lon], literally Saint John of Losne) is a commune in the Côte-d'Or department in eastern France. It is about 25 km (16 mi) southeast of Dijon.

Despite its size, the town's position on the Saône River meant it featured in a number of battles. In October 1636, during the Thirty Years War, the fortress was besieged by an Imperial army; the garrison commander, Mothe-Houdancourt, held out long enough to be relieved.

During the closing stages of the Napoleonic Wars in January 1814, the local inhabitants repelled several attempts by the Austrians to seize the bridge. In recognition, Napoleon awarded the town the Legion of Honour, which still appears on the coat of arms.

Historical population

Year	Pop.	±%
1962	1,528	—
1968	1,623	+6.2%
1975	1,605	−1.1%
1982	1,476	−8.0%
1990	1,342	−9.1%
1999	1,257	−6.3%
2008	1,204	−4.2%

• Canal de Bourgogne
• Communes of the Côte-d'Or department

• Jacques, Tony (2007). Dictionary of Battles and Sieges: P-Z. Greenwood. ISBN 978-0313335396.