Saint-Marc (Haitian Creole: Sen Mak) is an arrondissement in Artibonite department of Haiti. It has 268,499 inhabitants. Postal codes in the Saint-Marc Arrondissement start with the number 43.

The arrondissement consists of the following municipalities:

• Saint-Marc
• La Chapelle
• Verrettes
• Montrouis
• Liancourt