UCSF Health Saint Francis Hospital, formerly known as Saint Francis Memorial Hospital, is an accredited, not-for-profit community hospital that has been operating since the early twentieth century in San Francisco, California, United States. It is located at 900 Hyde Street, at the corner of Bush street, near the Tenderloin and Nob Hill neighborhoods.

Saint Francis Memorial was a member of Dignity Health starting in 1993, and later part of CommonSpirit Health in 2019. In July 2023, the University of California, San Francisco Medical Center (or UCSF Health) announced its intention to acquire both Saint Francis Memorial Hospital, and St. Mary's Medical Center from Dignity Health.

Founded in 1905 in San Francisco by five physicians, they undertook to build "the most up-to-date modern hospital west of Chicago." It was not founded as a Catholic hospital, despite its name. The campus also contained a school for female students, the Saint Francis Memorial Hospital School of Nursing, which also founded in 1905. After the 1906 San Francisco earthquake and fire, the hospital campus burned down and it was moved to a temporary location at 2828 California Street by Dr. Redmond Payne and volunteers. In 1909, the hospital was moved to the former Morton Hospital campus (1904–1909), at 778 Cole Street, which only had some 30 beds.

In 1911, it opened a hospital campus its present address on 900 Hyde Street which offered 100 beds. In 1921, they expanded and added a 200-bed obstetrics wing. In 1938, it became the non-profit Saint Francis Hospital Association.

The Bothin Burn Center opened in 1967 as a 10-bed acute care ward, led by Dr. James Macho. In 1979, the Center for Sports Medicine opened, led by Dr. James Garrick; and was the first sports medicine program located in a hospital. In 1990, the Spine Center opened, under the leadership of Dr. Kenneth Light.

In 2001, the Total Joint Center opened, led by Dr. Thomas Sampson and Dominic Tse.

• 1911: A new 100-bed building is built at the corner of Bush and Hyde streets, which is the present Nob Hill address, and is fully occupied within 10 days of opening.
• 1921: To accommodate the post-war baby boom, a 200-bed obstetrics wing is added.
• 1938: The for-profit Saint Francis Hospital Company becomes the non-profit Saint Francis Hospital Association.
• 1952: The Plastic & Reconstructive Surgery Clinic and Residency Program is established.
• 1955: A four-bed burn ward opens. Occupational Therapy and Social Services are added for the benefit of the community.
• 1965: Groundbreaking for the new tower takes place.
• 1984: $3.5 million is raised for major hospital renovations.
• 1986: The Healthwise Senior Program is started and serves the senior citizens of San Francisco.
• 1990: Saint Francis becomes the first hospital in the San Francisco/Bay Area to perform Laser Gall Bladder Surgery. The HIVCare Program is established. The Centers for Excellence adds an Oncology Center and a Spine Center.
• 1993: Saint Francis becomes a member of Dignity Health.
• 1999: Dignity and Saint Francis become the Official Health Care Provider of the San Francisco Giants.
• 2000: Saint Francis opens The Health Center at the old SBC Park.
• 2002: One of the top scores within the Dignity Hospital System, Saint Francis receives a score of 94 during the JCAHO/CALS survey.
• 2003: The Hospital installs the Picture archiving and communication System (PACS) in the Radiology Department, one of the newest systems.
• 2004: The Behavioral Health Day Unit and the San Francisco Center for Wound Healing begin operations.
• 2005: The Center for Sports Medicine opens a new satellite center in Corte Madera at the Town Center.
• A satellite Center for Sports Medicine is added to the new AT&T Park and a third center is opened in Walnut Creek, Ca.

• List of hospitals in California
• Dignity Health

• Official website

37°47′21″N 122°25′01″W / 37.789229°N 122.416982°W / 37.789229; -122.416982