St. Paul University Quezon City (SPUQC), also referred to as SPU Quezon City, is a private, sectarian and coeducational university located in New Manila, Quezon City, Philippines. It was previously an all-girls' school and turned co-ed beginning school year 2006-2007.

In June 2006, SPUQC started to admitting men who pursuing college education. The High School Department followed suit when the first set of graduates from the co-ed Grade School enrolled in the High School in June 2008. Its sister school St. Paul College Pasig remained an exclusive all-girls school.

It is a charter member of the Philippine Accrediting Association of Schools, Colleges and Universities (PAASCU).

It is one of the 40 schools owned, managed, and operated by the Sisters of St. Paul of Chartres (SPC) in the Philippines.

It is one of the seven campuses comprising the St. Paul University System.

The college was established as St. Paul College Quezon City Branch in 1946. It was founded by the Sisters of St. Paul of Chartres (SPC), a congregation established in Chartres, France, by Father Louis Chauvet in 1696. The college originally catered to young women of the upscale New Manila area.

The Liberal Arts and Commerce programs were first granted accreditation status by PAASCU in 1983 along with the High School Department. The application for the accreditation of the Science programs followed in 1989. All these programs have periodically been granted re-accreditation status since then.

The grade school was initially offered to boys and girls. Eventually, the high school and college levels were exclusively offered to women, making the school a full women's college in 1966.

The college enjoys full autonomy status from the Commission on Higher Education of the Philippines. It was also awarded a Level III Accreditation (the second highest possible level) by the Philippine Accrediting Association of Schools, Colleges, and Universities (PAASCU).

The college is also part of the Women's Consortium Colleges which includes Miriam College in Katipunan, Assumption College San Lorenzo in Makati, La Consolacion College Manila in Mendiola, and the College of the Holy Spirit Manila in Mendiola.

• Rhea Santos (Mass Communication Batch 2000) - GMA-7 newscaster
• Tootsie Guevara (Hotel and Restaurant Management Batch 2003) - Former ABS-CBN actress, Singer and Recording artist.
• Liezl Sumilang-Martinez - Actress and MTRCB Board
• Maxine Medina (HS Batch 2009) - Miss Universe Philippines 2016
• Alex Gonzaga (HS Batch) - Actress and Vlogger
• Adeline Dumapong-Ancheta (Computer Science) - Filipina Paralympic powerlifter
• Cristina Pantoja-Hidalgo (HS Batch, Valedictorian) - Fictionist, critic, and pioneering writer of Creative nonfiction.
• Maureen Larrazabal (Communication Arts in Interior Design) - Actress, singer, and model.
• Nikki Coseteng - Former Senator of the Philippines from 1992 to 2001.
• K Brosas (HS and Tourism Management) - A Filipino actress, comedian, singer and television host.
• Ma-an Asuncion-Dagñalan (Mass Communication Batch 1994) - an acclaimed director and scriptwriter, who won Best Director at the 2022 Cinemalaya Film Festival and the Filipino Academy of Movie Arts and Sciences Awards (FAMAS) 2023. She also gained international recognition, serving as a Pro Online Delegate at the 74th Locarno International Film Festival and winning Best Foreign Film at the LA Femme International Film Fest at La Femme International Film Fest 2023 for her film "Blue Room".
• Paula Camille L. Biluan (Communication Batch 2010) - Outstanding Personnel for Administration by the Philippine National Police in 2023.

• St. Paul University Philippines, Tuguegarao
• St. Paul University Manila, Manila (proper)
• St. Paul University Dumaguete, Negros Oriental
• St. Paul University Iloilo, Iloilo City
• St. Paul University Surigao, Surigao del Norte

• Official website
• Media related to St. Paul University Quezon City at Wikimedia Commons