Salem Veteran Affairs Medical Center (VAMC) is a Veterans Affairs hospital located in Salem, Virginia. Health care services are provided to veterans living in a 26-county area of Southwest Virginia. In addition to the main facility in Salem, there are affiliated services in three community-based outpatient clinics. These clinics are located in Danville, Lynchburg, Tazewell, Wytheville, and Staunton.

The Roanoke Veterans Administration Hospital Historic District is a national historic district encompassing 34 contributing buildings, 2 contributing sites, 17 contributing structures, and 1 contributing object. Construction began on the Roanoke (now Salem) VA Hospital in 1934, and various additions were constructed through 1950. The Main Building (1934) is situated on a raised elevation over the front lawn and serves as the focal point of the historic district. Other buildings include the Administration Building (1934), Dining Hall/Attendants’ Quarters (1934), Recreation Building (1934), Colored Patients’ Building (1934), four Continued Treatment Buildings (1938, 1941, 1940, 1938), and Neuropsychiatric Infirmary Building (1936). The buildings exhibit the Colonial Revival and Classical Revival architectural styles that were nationally popular at the time. It was listed on the National Register of Historic Places in 2012.

• Salem VA Medical Center homepage
• Historic American Buildings Survey (HABS) No. VA-1251, "Roanoke Veterans Administration Hospital, 1970 Roanoke Boulevard, Salem, Salem, VA", 67 data pages
• Historic American Buildings Survey (HABS) No. VA-1251-A, "Roanoke Veterans Administration Hospital, Building No. 6, 1970 Roanoke Boulevard, Salem, Salem, VA", 20 photos, 34 data pages, 2 photo caption pages