Saline County Courthouse is a historic courthouse located at Marshall, Saline County, Missouri. It was designed by John C. Cochrane and built in 1882–1883. It is a two-story, cruciform plan, red brick building and measures 100 feet by 110 feet. It features a four-stage, square clock tower with a pyramidal slate roof atop the intersecting wings.

It was added to the National Register of Historic Places in 1977.