Samuel von Brukenthal National College (German: Samuel-von-Brukenthal-Gymnasium, Romanian: Colegiul Național "Samuel von Brukenthal", Hungarian: Samuel von Brukenthal Főgimnázium) is a German-language high school founded in Nagyszeben, Transylvania, Kingdom of Hungary, today in Sibiu (German: Hermannstadt), Sibiu County, Romania, located at 5 Albert Huet Square.

The school is named after baron Samuel von Brukenthal, governor of the Grand Principality of Transylvania between 6 July 1774 and 9 January 1787. The earliest record of the school is from 1380, making it the oldest German-language school on the territory of present-day Romania. The current school building was built between 1779 and 1786 on the site of an earlier school, and is classified as a historical monument with LMI code SB-II-m-A-12082.

• Septimiu Albini (1861–1919), journalist and political activist
• Romulus Cândea (1886–1973), ecclesiastical historian
• Dimitrie Comșa (1846–1931), agronomist and political activist
• Arthur Coulin (1869–1912), painter and art critic
• Bernd Fabritius (born 1965), German politician
• Klaus Johannis, President of Romania (2014–present)
• Karl Kurt Klein [ro] (1897–1971), theologian and writer
• Friedrich Müller-Langenthal [ro] (1884–1969), historian and theologian
• Rubin Patiția (1841–1918), lawyer and political activist
• Daniil Popovici-Barcianu (1847–1903), teacher, naturalist, and political activist
• Arthur Arz von Straußenburg (1857–1935), Chief of the General Staff of the Austro-Hungarian Army
• Viorel Tilea (1896–1972), diplomat

• Official website