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San Isidro (Spanish pronunciation: [san iˈsiðɾo]) is a municipality in the Matagalpa department of Nicaragua.

v t e Matagalpa Department
Capital: Matagalpa
Municipalities	Ciudad Darío Esquipulas Matagalpa Matiguás Muy Muy Rancho Grande Río Blanco San Dionisio San Isidro San Ramón Sébaco Terrabona Tuma-La Dalia

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