San Jorge is a municipality in the Honduran department of Ocotepeque.

At the time of the 2013 Honduras census, San Jorge municipality had a population of 5,037. Of these, 97.08% were Mestizo, 1.39% Indigenous (0.89% Lenca, 0.42% Chʼortiʼ), 1.31% Black or Afro-Honduran and 0.22% White.

14°39′0″N 89°8′0″W / 14.65000°N 89.13333°W / 14.65000; -89.13333