San Lucas Camotlán is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of 127.58 km. It is part of the Sierra Mixe district within the Sierra Norte de Oaxaca Region.

As of 2005, the municipality had 518 households with a total population of 2,524 of whom 2,168 spoke an indigenous language. About 90% of the population is engaged in agriculture, and 10% in animal husbandry. The Union of Indigenous Communities of the Isthmus Region, a cooperative founded in 1982, assists in production and distribution of the local products, notably coffee, under a fair trade label.