San Quirino (Friulian: San Quarìn) is a comune (municipality) in the Regional decentralization entity of Pordenone in the Italian region of Friuli-Venezia Giulia, located about 100 kilometres (62 mi) northwest of Trieste and about 8 kilometres (5 mi) northeast of Pordenone.

San Quirino borders the following municipalities: Aviano, Cordenons, Maniago, Montereale Valcellina, Pordenone, Roveredo in Piano, Vivaro.