The San Roque González de Santa Cruz Bridge is a 2,550 metres (8,366 ft) long cable-stayed bridge that crosses the Paraná River between the cities of Posadas, capital of Misiones Province, Argentina and Encarnación, capital of Itapúa, Paraguay. The main bridge is 570 metres (1,870 ft) long and the approaching viaduct is 1,595 metres (5,233 ft) long.

The bridge, named for the founder of the missions which evolved into both cities, was first projected in 1977 through an agreement between the governments of Argentina and Paraguay, as a compensation to Paraguay for the flooding of part of its territory by the Yacyretá Dam. Its construction began in 1981 and was planned to last three years, but was finished only in 1990. It was construct by a consortium leading by the Italian company Impregilo.

The road-rail bridge also carries the Posadas-Encarnacion International Train.

• General Urquiza Railway
• Rail transport in Paraguay