Sant'Ippolito Martire (Italian is a Baroque, Roman Catholic parish church in Palermo, region of Sicily, Italy. It is located on a busy street with markets, on via Porta Carini in the Capo quarter, across the street from the church of the Immacolata Concezione al Capo.

A parish church at the site is first mentioned in 1308. In 1583, during the Spanish rule of Sicily, the church was expanded; but the present church is a product of a refurbishment started in 1717 using designs by Andrea Palma. His grandson, Nicolò Palma, helped restore the church in 1769 and a further refurbishment was performed in 1844 under Giovanni Patricolo, who directed some of the fresco decoration.

The entrance portal has bas-reliefs of Saints Peter, Hippolytus, and Paul. The Latin Cross layout has three naves with lateral chapels. The nave ceiling has a fresco depicting Jesus in Lake Tiberius, retouched in the 1950s.

• Gaspare Palermo, Guida istruttiva per potersi conoscere tutte le magnificenze della Città di Palermo, Volume IV, Palermo, Reale Stamperia, 1816, pages 52-56.