Santa Cruz Itundujia is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km². It is part of Putla District in the west of the Sierra Sur Region.

As of 2020, the municipality had a total population of 967 habitantes .<reff>"-". Enciclopedia de los Municipios de México. Instituto Nacional para el Federalismo y el Desarrollo Municipal. Retrieved June 12, 2009.</ref>