Santa Mesa is a district in Manila, Philippines. It is surrounded by the Pasig River on the southwestern side, and by the San Juan River on its southern and eastern side. Land borders include the districts of San Miguel to the west and Sampaloc to the north; and to the northeast is Quezon City.

Santa Mesa was formerly a part of the Sampaloc district, from which it was partitioned and separated after it had its own parish in 1911. The parish is now known as Old Sta. Mesa (Poblacion), which extends from Victorino Mapa Street (Calle Santa Mesa) to Magsaysay Boulevard (Santa Mesa Boulevard).

The district's name comes from the Jesuits, who christened the area Hermandad de Santa Mesa de la Misericordia (Spanish for "Brotherhood of the Holy Table of Mercy"). The local parish church had for its titular Sacred Heart of Jesus, which formed part of the phrase the "Center of the Table is the Sacred Heart which all Graces and Mercy flowed down." The Tuason family are the landlords of Santa Mesa during the Spanish colonial period offered an obra pía ("pious work"), and provided social services to the people Doña Albina Tuason also donated the Land where the Church is located even right at this modern days.

A more popular folk etymology is that the name is a corruption of the Spanish term Santa Misa ("Holy Mass").

Santa Mesa was situated in the alluvial deposits at the confluence of Pasig and San Juan Rivers. It was owned by a Jesuits religious order during the Spanish era, and it is in this period that Santa Mesa got its name. Santa Mesa is better known for its role in the Philippine–American War, in which the area became a battlefield during the Philippine–American War. The conflict started when Pvt. William W. Grayson shot a Filipino soldier in San Juan Bridge between Santa Mesa and San Juan. In late 2003, the National Historical Commission of the Philippines had determined that the conflict did not happen on San Juan Bridge, but at the juncture of Sociego and Silencio Streets.

Up until the early American period, Santa Mesa was one of the barrios that comprised Sampaloc, which was a town of the defunct province of Manila before it was absorbed by the city of Manila upon its chartering in 1901. In 1911, Santa Mesa became a separate religious district out of Sampaloc when the first and oldest parish in the Philippines in honor of its titular patron, the Sacred Heart of Jesus, was established. The created parish is now known as the Old Santa Mesa, which extended from V. Mapa to Santa Mesa Boulevard. The neighborhood was composed of wealthy and aristocratic Spanish and Filipino families who built summer houses, examples of which are the Sociego Mansion, formerly home of the Tuason family, and the Carriedo Mansion (currently known as the Antique House in Pureza), formerly home of Governor General Francisco Carriedo y Peredo who spearheaded the clean water system of the City of Manila. Affluent families where attracted to Santa Mesa's cooler climate and the picturesque streets that were lined with ylang-ylang trees along Santa Mesa Boulevard. The abundance of these trees started a perfume industry in Santa Mesa—flowers were harvested, pressed and the oil were exported in great quantities to perfumeries in France. However, for political purposes, Santa Mesa remained part of Sampaloc.

The small community became the location of the hospital to treat the wounded during World War II. The town experienced its growth after the war. Santa Mesa was the site of a 1950s suburban development because of its proximity to central Manila. The Santa Mesa Market was constructed around this period. It was a big shopping complex, and became popular for the selling of Post eXchange or PX Goods from U.S. bases in the Philippines, which is why it was called Stop & Shop.

When the congressional districts of Manila were created, Santa Mesa was effectively separated from Sampaloc, falling to the jurisdiction of the 6th District. The national census still considers Santa Mesa as a part of Sampaloc for statistical purposes.

Santa Mesa is located in the eastern section of the City of Manila. It is bounded to the west by Lacson Avenue separating it from San Miguel; by Ramon Magsaysay Boulevard to the north bordering it from Sampaloc. The northeast boundary of Santa Mesa is west of SM City Sta. Mesa shopping mall. Although the mall has "Santa Mesa" on its name, it is located in Quezon City very near the city limits of Manila.

The southwestern side of Santa Mesa is along the Pasig River while the southern and eastern sides are along the San Juan River. Across the San Juan River are the cities of San Juan to the east and a small portion of Mandaluyong to the southeast. Across the Pasig River, are the Manila areas of Santa Ana to the south and Pandacan to the southeast.

The topography of the area is relatively flat as some of the natural variations in elevations have been evened out due to urbanization.

• Bacood
• Banda Kawayan Pilipinas (Bamboo Band Philippines)
• United Church of Christ in the Philippines (UCCP - Bacood)
• Philippine Independent Church Bacood (Good Shepherd Parish)
• Mabini Shrine (Manila), former home of Apolinario Mabini, Philippines Revolution hero, located inside PUP.
• Our Lady of Lourdes Hospital
• Polytechnic University of the Philippines
• Recurso de Madriaga Pescado
• Sacred Heart of Jesus Catholic School
• Carriedo Mansion ( former home of the Governor General Don Francisco Carriedo y' Peredo who made the water system project of Manila)

Churches of Santa Mesa

Name	Image	Location / GPS Coordinates	Denomination	Notes
Baptist Bible Church		Sociego Street	Baptists
Gloria Dei Lutheran Church		Old Santa Mesa Street	Lutheran
Jehovah's Witness Kingdom Hall		Old Santa Mesa Street	Jehovah's Witnesses
Nuestra Señora de Salvacion Parish Church		Anonas Street cor Hipodromo Street	Roman Catholic
Our Lady of Fatima Parish Church		Lubiran Street cor. Mag. Jose Abad Santos Street	Roman Catholic
Sacred Heart of Jesus Parish Church		Old Santa Mesa Street	Roman Catholic
Sambahan sa Banal na Hapag (IEMELIF Church)		Magsaysay Boulevard	Methodist
Seventh-day Adventist Church		Hippodromo Street	Adventist
SM Valenzuela (IEMELIF Church)		Old Santa Mesa Street	Methodist
Abundant Life Ministry Inc.		Teresa Street	Born Again

Parks and plazas in Santa Mesa

Name	Image	Location / GPS Coordinates	Notes
Bacood Park		Valenzuela Street
Paraiso ng Batang Maynila		Bataan cor. Leyte Streets, Bacood
PUP Lagoon		PUP Mabini Campus, Anonas Street
PUP Linear Park		PUP Mabini Campus, Anonas Street
PUP Nemesio E. Prudente Freedom Park (Freedom Plaza)		PUP Mabini Campus, Anonas Street

Santa Mesa is made up of 51 barangays, grouped into seven zones of the City of Manila. For statistical convenience for housing and population, the data for Santa Mesa is grouped with the data of Sampaloc.

Zones

• Zone 58: Barangays 587 to 593
• Zone 59: Barangays 594 to 601
• Zone 60: Barangays 602 to 606 and 610 to 613
• Zone 61: Barangays 607 to 609 and 614 to 618
• Zone 62: Barangays 619 to 625
• Zone 63: Barangays 626 to 630
• Zone 64: Barangays 631 to 636

Barangays

Barangay	Land area (km)	Population (2020)
Zone 58
Barangay 587	0.07333 km	2,920
Barangay 587-A	0.02194 km	1,277
Barangay 588	0.01947 km	989
Barangay 589	0.03283 km	660
Barangay 590	0.03619 km	3,209
Barangay 591	0.06667 km	2,498
Barangay 592	0.03228 km	2,371
Barangay 593	0.04383 km	1,775
Zone 59
Barangay 594	0.03035 km	636
Barangay 595	0.04867 km	4,198
Barangay 596	0.02226 km	2,375
Barangay 597	0.03043 km	1,672
Barangay 598	0.07679 km	12,027
Barangay 599	0.03596 km	4,272
Barangay 600	0.06367 km	5,892
Barangay 601	0.1163 km	7,759
Zone 60
Barangay 602	0.1353 km	2,000
Barangay 603	0.04759 km	712
Barangay 604	0.02000 km	1,477
Barangay 605	0.03845 km	1,751
Barangay 606	0.03072 km	532
Barangay 610	0.02922 km	968
Barangay 611	0.03176 km	808
Barangay 612	0.02191 km	703
Barangay 613	0.02612 km	568
Zone 61
Barangay 607	0.04699 km	1,782
Barangay 608	0.02579 km	756
Barangay 609	0.02867 km	1,046
Barangay 614	0.01654 km	404
Barangay 615	0.02034 km	1,828
Barangay 616	0.03139 km	910
Barangay 617	0.03125 km	921
Barangay 618	0.04016 km	740
Zone 62
Barangay 619	0.2010 km	1,283
Barangay 620	0.02244 km	725
Barangay 621	0.07931 km	1,787
Barangay 622	0.02481 km	1,197
Barangay 623	0.02529 km	954
Barangay 624	0.02421 km	1,429
Barangay 625	0.03206 km	1,027
Zone 63
Barangay 626	0.03282 km	1,285
Barangay 627	0.04027 km	1,605
Barangay 628	0.1839 km	15,202
Barangay 629	0.03937 km	1,633
Barangay 630	0.2551 km	4,660
Zone 64
Barangay 631	0.04890 km	1,254
Barangay 632	0.01467 km	254
Barangay 633	0.01554 km	447
Barangay 634	0.05924 km
Barangay 635	0.05317 km	660
Barangay 636	0.08512 km	2,135

• City of Manila – Official website
• Geographic data related to Santa Mesa at OpenStreetMap

14°36′N 121°01′E / 14.600°N 121.017°E / 14.600; 121.017