Santo Stefano a Macerata is a village in Tuscany, central Italy, administratively a frazione of the comune of Cascina, province of Pisa. At the time of the 2001 census its population was 86.

Santo Stefano a Macerata is about 20 kilometres (12 mi) from Pisa and 7 kilometres (4.3 mi) from Cascina. The main hamlet of the frazione is called Chiesanuova.

The frazione is home to the European Gravitational Observatory and the Virgo interferometer, one of the few facilities in the world for the search for gravitational waves.

• Virgo interferometer