Santo Tomás a town in Ensenada Municipality, Baja California, on the Pacific Coast of Mexico. Santo Tomás is a primarily a wine-growing region, though it is increasingly a tourist destination.

It was originally the site of the Misión Santo Tomás de Aquino. After the mission was abandoned, it was taken as a post for the Mexican frontier garrison and for a time as the capital of the territory of Baja California. The town grew up east of the Mission site.

Santo Tomás is a wine-growing region, home to numerous vineyards and wineries. Since the rise in popularity of Valle de Guadalupe as a premier wine region in Baja California, Santo Tomás has begun to develop tourist accommodations, such as hotels and fine dining.

• Spanish missions in California

• Meigs, Peveril, III. 1935. The Dominican Mission Frontier of Lower California. University of California Publications in Geography No. 7. Berkeley.
• Vernon, Edward W. 2002. Las Misiones Antiguas: The Spanish Missions of Baja California, 1683-1855. Viejo Press, Santa Barbara, California.

31°33′16″N 116°24′32″W / 31.55444°N 116.40889°W / 31.55444; -116.40889